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EP 4 771 139 A1

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(43) Date of publication: 08.07.2026 Bulletin 2026/28 (21) Application number: 24772860.3 (22) Date of filing: 30.08.2024

(51) International Patent Classification (IPC):  C12N 9/22(2006.01) (52) Cooperative Patent Classification (CPC): C12N 9/22 (86) International application number: PCT/US2024/044664 (87) International publication number: WO 2025/049900 (06.03.2025 Gazette 2025/10)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 01.09.2023 US 202363580173 P 01.09.2023 US 202363580193 P 15.02.2024 US 202463553840 P 25.04.2024 US 202463638552 P (71) Applicant: Arbor Biotechnologies, Inc. Cambridge, MA 02140 (US)

(72) Inventors: ALFONSE, Lauren E. Cambridge, Massachusetts 02140 (US) MABEN, Zachary J. Cambridge, Massachusetts 02140 (US) TORGERSON, Chad D. Cambridge, Massachusetts 02140 (US) WATTERS, Kyle E. Cambridge, Massachusetts 02140 (US) (74) Representative: Maiwald GmbH  Elisenhof Elisenstraße 3 80335 München 80335 München (DE)