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EP 4 771 140 A1

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(43) Date of publication: 08.07.2026 Bulletin 2026/28 (21) Application number: 24776067.1 (22) Date of filing: 30.08.2024

(51) International Patent Classification (IPC):  C12N 9/22(2006.01) C12N 5/00(2006.01) C07K 16/00(2006.01) C12N 5/10(2006.01) (52) Cooperative Patent Classification (CPC): C12N 9/22; C07K 16/44 (86) International application number: PCT/US2024/044671 (87) International publication number: WO 2025/049905 (06.03.2025 Gazette 2025/10)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 01.09.2023 US 202363580228 P (71) Applicant: Yale University New Haven CT 06510 (US)	(72) Inventors: SQUINTO, Stephen New York, NY 10021 (US) LUDWIG, Dale Pennington, NJ 05834 (US) QUIJANO, Elias New Haven, CT 06510 (US) GLAZER, Peter New Haven, CT 06510 (US) BLECK, Gregory Middleton, WI 056562 (US) (74) Representative: Hoffmann Eitle  Patent- und Rechtsanwälte PartmbB Arabellastraße 30 81925 München 81925 München (DE)