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EP 4 771 163 A1

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(43) Date of publication: 08.07.2026 Bulletin 2026/28 (21) Application number: 24860939.8 (22) Date of filing: 28.08.2024

(51) International Patent Classification (IPC):  C12N 15/85(2006.01) C12N 5/071(2010.01) A61K 9/127(2025.01) C12N 15/87(2006.01) A61K 48/00(2006.01) A61P 3/10(2006.01) (52) Cooperative Patent Classification (CPC): A61P 3/10; C12N 15/85; C12N 2800/107; C12N 5/0676; C12N 2510/00; C12N 2501/60; C12N 2506/1307 (86) International application number: PCT/US2024/044212 (87) International publication number: WO 2025/049594 (06.03.2025 Gazette 2025/10)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 28.08.2023 US 202363579128 P (71) Applicant: Ohio State Innovation Foundation Columbus, OH 43201 (US)	(72) Inventors: GALLEGO-PEREZ, Daniel Columbus, Ohio 43221 (US) LEMMERMAN, Luke Columbus, Ohio 43201 (US) HIGUITA-CASTRO, Natalia Columbus, Ohio 43221 (US) GOTSCHALL, Andrew Joseph Carrollton, Ohio 44615 (US) (74) Representative: Moré, Solveig Helga et al Kroher Strobel Rechts- und Patentanwälte PartmbB Bavariaring 20 80336 München 80336 München (DE)