(19)
(11) EP 4 771 164 A1

(12)

(43) Date of publication:
08.07.2026 Bulletin 2026/28

(21) Application number: 24861081.8

(22) Date of filing: 29.08.2024
(51) International Patent Classification (IPC): 
C12N 15/85(2006.01)
C12N 5/0783(2010.01)
A61K 35/17(2025.01)
C07K 14/315(2006.01)
C07K 19/00(2006.01)
 C12N 15/86(2006.01)
C12N 9/22(2006.01)
A61K 38/46(2006.01)
C12N 15/62(2006.01)
A61K 9/51(2006.01)
(52) Cooperative Patent Classification (CPC):
A61K 35/17; C07K 14/315; C12N 15/113; C12N 15/907; A61K 40/11; A61K 40/15; A61K 40/31; A61K 40/4211; C12N 9/222; C12N 2510/00; C12N 5/0636; C12N 2310/20
(86) International application number:
PCT/US2024/044538
(87) International publication number:
WO 2025/049816 (06.03.2025 Gazette 2025/10)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
GE KH MA MD TN

(30) Priority: 30.08.2023 US 202363535412 P

(71) Applicant: Full Circles Therapeutics Inc.
Cambridge, MA 02138 (US)

(72) Inventors:
  • XIE, Keqiang
    Cambridge, Massachusetts 02138 (US)
  • WANG, Jiao
    Cambridge, Massachusetts 02138 (US)
  • STARZYK, Jakob
    Cambridge, Massachusetts 02138 (US)
  • SHAN, Qun
    Cambridge, Massachusetts 02138 (US)
  • WU, Hao
    Cambridge, Massachusetts 02138 (US)

(74) Representative: Dr. Langfinger & Partner 
Grüneburgweg 119
60323 Frankfurt am Main
60323 Frankfurt am Main (DE)

   


(54) METHOD FOR ENGINEERING OF IMMUNE CELLS EXPRESSING CHIMERIC ANTIGEN RECEPTORS AT IMMUNE CHECKPOINT LOCI FOR DISEASE TREATMENT