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EP 4 771 184 A1

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(43) Date of publication: 08.07.2026 Bulletin 2026/28 (21) Application number: 24861152.7 (22) Date of filing: 30.08.2024

(51) International Patent Classification (IPC):  C12Q 1/6881(2018.01) C12Q 1/6869(2018.01) G01N 33/68(2006.01) A61K 39/00(2006.01) (52) Cooperative Patent Classification (CPC): C12Q 1/6881; C12Q 1/6869 (86) International application number: PCT/US2024/044692 (87) International publication number: WO 2025/049921 (06.03.2025 Gazette 2025/10)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 30.08.2023 US 202363535326 P (71) Applicants: University of Louisville Research Foundation, Inc. Louisville, KY 40202 (US) Smith, Melissa L. Louisville, Kentucky 40207 (US) Watson, Corey T. Louisville, Kentucky 40205 (US)

(72) Inventors: SMITH, Melissa L. Louisville, Kentucky 40207 (US) WATSON, Corey T. Louisville, Kentucky 40205 (US) (74) Representative: Henderson, Helen Lee  Withers & Rogers LLP 2 London Bridge London SE1 9RA London SE1 9RA (GB)