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EP 4 771 381 A1

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(43) Date of publication: 08.07.2026 Bulletin 2026/28 (21) Application number: 24769202.3 (22) Date of filing: 26.08.2024

(51) International Patent Classification (IPC):  G01N 30/96(2006.01) G01N 27/447(2006.01) G01N 33/15(2006.01) G01N 21/59(2006.01) B01D 15/36(2006.01) G01N 30/86(2006.01) G01N 30/88(2006.01) (52) Cooperative Patent Classification (CPC): G01N 2030/8831; G01N 30/96; B01D 15/362; G01N 30/8679; G01N 33/15; G01N 27/447; B01D 15/327 (86) International application number: PCT/US2024/043843 (87) International publication number: WO 2025/049384 (06.03.2025 Gazette 2025/10)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 31.08.2023 US 202363579844 P (71) Applicant: Amgen Inc. Thousand Oaks, California 91320-1799 (US)

(72) Inventors: WANG, Sean Thousand Oaks, California 91320-1799 (US) HAPUARACHCHI, Suminda Thousand Oaks, California 91320-1799 (US) ZHANG, Qingchun Thousand Oaks, California 91320-1799 (US) KUHNS, Scott Thomas Thousand Oaks, California 91320-1799 (US) HE, Lidong Thousand Oaks, California 91320-1799 (US) GUAN, Xiaoyan Thousand Oaks, California 91320-1799 (US) (74) Representative: Dörries, Hans Ulrich  df-mp Patentanwälte Rechtsanwälte PartG mbB Theatinerstraße 16 80333 München 80333 München (DE)