(19)

(11)

EP 4 771 385 A1

(12)

(43) Date of publication: 08.07.2026 Bulletin 2026/28 (21) Application number: 24860987.7 (22) Date of filing: 29.08.2024

(51) International Patent Classification (IPC):  G01N 33/50(2006.01) A61K 38/20(2006.01) A61K 35/17(2025.01) G01N 33/92(2006.01) (52) Cooperative Patent Classification (CPC): A61K 35/17; G01N 33/6896; G01N 2800/52; G01N 2800/2835; A61K 38/2013; A61K 31/192; A61K 31/575; A61K 31/4152; A61K 31/428; A61P 25/28   C-Sets: A61K 31/575, A61K 2300/00; A61K 31/4152, A61K 2300/00; A61K 31/428, A61K 2300/00; A61K 38/2013, A61K 2300/00; A61K 35/17, A61K 2300/00; A61K 31/192, A61K 2300/00; (86) International application number: PCT/US2024/044320 (87) International publication number: WO 2025/049671 (06.03.2025 Gazette 2025/10)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 30.08.2023 US 202363535524 P (71) Applicants: The Methodist Hospital Houston, Texas 77030 (US) Coya Therapeutics, Inc. Houston, TX 77024 (US)	(72) Inventors: APPEL, Stanley, Hersh Houston, TX 77004 (US) BEERS, David, Robert Houston, TX 77096 (US) BERMAN, Howard Houston, TX 77063 (US) (74) Representative: Jones Day  Gewürzmühlstr. 11 80538 München 80538 München (DE)