(19)
(11) EP 4 771 627 A1

(12)

(43) Date of publication:
08.07.2026 Bulletin 2026/28

(21) Application number: 24861092.5

(22) Date of filing: 29.08.2024
(51) International Patent Classification (IPC): 
G16B 20/20(2019.01)
G16B 40/00(2019.01)
G16B 30/10(2019.01)
(52) Cooperative Patent Classification (CPC):
G16B 20/20
(86) International application number:
PCT/US2024/044556
(87) International publication number:
WO 2025/049830 (06.03.2025 Gazette 2025/10)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
GE KH MA MD TN

(30) Priority: 30.08.2023 US 202363535450 P

(71) Applicant: Grail, Inc.
Menlo Park, California 94025 (US)

(72) Inventors:
  • CALEF, Robert Abe Pain
    Menlo Park, CA 94025 (US)
  • FIELDS, Alexander P.
    Menlo Park, CA 94025 (US)
  • VENN, Oliver Claude
    Menlo Park, CA 94025 (US)

(74) Representative: Murgitroyd & Company 
165-169 Scotland Street
Glasgow G5 8PL
Glasgow G5 8PL (GB)

   


(54) IDENTIFICATION AND EXCLUSION OF VARIANTS WITH OUTLIER ALLELE FRACTIONS IN TUMOR FRACTION ESTIMATIONS