(19)

(11)

EP 4 797 953 A1

(12)

(43) Date of publication: 02.09.2026 Bulletin 2026/36 (21) Application number: 24805633.5 (22) Date of filing: 23.10.2024

(51) International Patent Classification (IPC):  A01K 67/0271(2024.01) C12N 9/22(2006.01) C12N 5/0789(2010.01) C12N 15/113(2010.01) (52) Cooperative Patent Classification (CPC): A01K 67/0271; A01K 2207/12; A01K 2207/15; C12N 5/0647; C12N 2510/00; A01K 2227/105; A01K 2267/0306; A01K 2267/0387; C12N 15/113; C12N 9/93; C12N 15/1137; C12N 2310/11; A61K 35/28; C12N 2310/20; A61P 7/00 (86) International application number: PCT/IB2024/060412 (87) International publication number: WO 2025/088508 (01.05.2025 Gazette 2025/18)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 24.10.2023 IT 202300022191 (71) Applicants: Fondazione Telethon ETS 00185 Roma (IT) Ospedale San Raffaele S.r.l. 20132 Milano (MI) (IT)	(72) Inventors: FERRARI, Samuele 20100 Milano (IT) NALDINI, Luigi 20100 Milano (IT) FIUMARA, Martina 20100 Milano (IT) MOLTENI, Raffaella 20100 Milano (IT) CAVALLI, Giulio 20100 Milano (IT) (74) Representative: Manfredi, Irene  ADV IP S.r.l. Corso di Porta Vittoria, 29 20122 Milano 20122 Milano (IT)