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EP 4 798 193 A1

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(43) Date of publication: 02.09.2026 Bulletin 2026/36 (21) Application number: 24883262.8 (22) Date of filing: 23.10.2024

(51) International Patent Classification (IPC):  A61K 31/405(2006.01) A61P 35/04(2006.01) A61K 31/366(2006.01) A61K 31/4418(2006.01) A61K 31/225(2006.01) (52) Cooperative Patent Classification (CPC): A61K 31/366; A61K 31/225; A61K 31/405; A61P 35/04; A61K 31/44; A61K 31/40 (86) International application number: PCT/US2024/052627 (87) International publication number: WO 2025/090648 (01.05.2025 Gazette 2025/18)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 24.10.2023 US 202363545424 P (71) Applicant: The Regents of University of California Oakland, CA 94607-5200 (US)

(72) Inventors: WU, Lily Los Angeles, California 90095-7191 (US) DAMOISEAUX, Robert D. Los Angeles, California 90095-7191 (US) ISHIHARA, Moe Los Angeles, California 90095-7191 (US) HU, Junhui (Daniel) Los Angeles, California 90095-7191 (US) CONWAY, Stuart Los Angeles, California 90095-7191 (US) BRODIE, Glen Los Angeles, California 90095-7191 (US) AMBROSSI, Nubia Los Angeles, California 90095-7191 (US) (74) Representative: Pearl Cohen UK  The Gridiron Building One Pancras Square London N1C 4AG London N1C 4AG (GB)