(19)
(11) EP 4 798 194 A1

(12)

(43) Date of publication:
02.09.2026 Bulletin 2026/36

(21) Application number: 24883384.0

(22) Date of filing: 25.10.2024
(51) International Patent Classification (IPC): 
A61K 31/424(2006.01)
A61K 31/39(2006.01)
C07D 413/14(2006.01)
C07D 513/04(2006.01)
A61P 35/02(2006.01)
 A61K 31/428(2006.01)
A61K 31/5377(2006.01)
C07D 498/04(2006.01)
A61P 35/00(2006.01)
(52) Cooperative Patent Classification (CPC):
A61P 35/00; A61P 35/02; A61K 31/4375; A61K 31/706; A61K 31/635; A61K 38/1793; A61K 38/2006
 
C-Sets:
  1. A61K 38/2006, A61K 2300/00;
  2. A61K 31/4375, A61K 2300/00;
  3. A61K 31/706, A61K 2300/00;
  4. A61K 31/635, A61K 2300/00;
  5. A61K 38/1793, A61K 2300/00;
(86) International application number:
PCT/US2024/052925
(87) International publication number:
WO 2025/090844 (01.05.2025 Gazette 2025/18)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
GE KH MA MD TN

(30) Priority: 27.10.2023 US 202363546016 P

(71) Applicant: Curis, Inc.
Lexington, MA 02421 (US)

(72) Inventors:
  • SEVERGNINI, Mariano
    Burlington, MA 01803 (US)
  • CHOUDHARY, Gaurav
    Westford, MA 01886 (US)
  • LANE, Maureen, E.
    Marshfield, MA 02050 (US)
  • NICKLE, David, C.
    San Diego, CA 92130 (US)
  • CARLISLE, Samantha, M.
    San Diego, CA 92130 (US)

(74) Representative: HGF 
HGF Limited 4th Floor, 1 City Square
Leeds LS1 2ES
Leeds LS1 2ES (GB)

   


(54) METHODS OF TREATING CANCER ASSOCIATED WITH REDUCED INTERLEUKIN 1 BETA EXPRESSION