(19)
(11) EP 4 798 195 A2

(12)

(88) Date of publication A3:
19.06.2025

(43) Date of publication:
02.09.2026 Bulletin 2026/36

(21) Application number: 24793817.8

(22) Date of filing: 22.10.2024
(51) International Patent Classification (IPC): 
A61K 31/427(2006.01)
A61K 31/635(2006.01)
A61K 31/713(2006.01)
A61P 35/02(2006.01)
 A61K 31/454(2006.01)
A61K 31/7105(2006.01)
A61K 45/06(2006.01)
(52) Cooperative Patent Classification (CPC):
A61K 31/427; A61K 31/454; A61K 45/06; A61P 35/02; A61K 31/635; A61K 31/7105; A61K 31/713
 
C-Sets:
  1. A61K 31/713, A61K 2300/00;
  2. A61K 31/427, A61K 2300/00;
  3. A61K 31/454, A61K 2300/00;
  4. A61K 31/635, A61K 2300/00;
  5. A61K 31/7105, A61K 2300/00;
(86) International application number:
PCT/EP2024/079767
(87) International publication number:
WO 2025/087879 (01.05.2025 Gazette 2025/18)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
GE KH MA MD TN

(30) Priority: 23.10.2023 EP 23306854

(71) Applicants:
  • Institut National de la Santé et de la Recherche Médicale
    75013 Paris (FR)
  • Centre National de la Recherche Scientifique
    75016 Paris (FR)
  • Université Paris Cité
    75006 Paris (FR)
  • Duke University
    Durham, NC 27705 (US)
  • Université de Montpellier
    34090 Montpellier (FR)
  • Ecole Nationale Supérieure de Chimie de Montpellier
    34296 Montpellier Cedex 5 (FR)

(72) Inventors:
  • PUISSANT, Alexandre
    75010 PARIS (FR)
  • WOOD, Kris
    DURHAM, North Carolina 27705 (US)
  • MARTIN, Anthony
    34293 MONTPELLIER CEDEX 5 (FR)

(74) Representative: Inserm Transfert 
PariSanté Campus 10 rue d'Oradour-sur-Glane
75015 Paris
75015 Paris (FR)

   


(54) SUPPRESSING THE PI3KGAMMA/AKT SIGNALLING PATHWAY FOR THE TREATMENT OF ACUTE MYELOID LEUKEMIA