(19)
(11) EP 4 798 199 A1

(12)

(43) Date of publication:
02.09.2026 Bulletin 2026/36

(21) Application number: 24805039.5

(22) Date of filing: 25.10.2024
(51) International Patent Classification (IPC): 
A61K 31/4436(2006.01)
A61K 31/44(2006.01)
A61K 31/506(2006.01)
A61K 45/06(2006.01)
 A61K 31/4184(2006.01)
A61K 31/4523(2006.01)
A61K 31/519(2006.01)
A61P 35/00(2006.01)
(52) Cooperative Patent Classification (CPC):
A61K 45/06; A61K 31/519; A61K 31/506; A61K 31/4184; A61K 31/44; A61K 31/4523; A61K 31/4436; A61P 35/00
 
C-Sets:
  1. A61K 31/4523, A61K 2300/00;
  2. A61K 31/4436, A61K 2300/00;
  3. A61K 31/519, A61K 2300/00;
  4. A61K 31/506, A61K 2300/00;
  5. A61K 31/4184, A61K 2300/00;
  6. A61K 31/44, A61K 2300/00;
(86) International application number:
PCT/US2024/053119
(87) International publication number:
WO 2025/090966 (01.05.2025 Gazette 2025/18)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
GE KH MA MD TN

(30) Priority: 26.10.2023 US 202363593487 P

(71) Applicant: Tahoe Therapeutics, Inc.
South San Francisco, CA, 94080 (US)

(72) Inventors:
  • YU, John
    South San Francisco, CA, 94080 (US)
  • TOUTOUNCHIAN, Jordan
    South San Francisco, CA, 94080 (US)
  • MERICO, Daniele
    South San Francisco, CA, 94080 (US)
  • ALIDOUST, Nima
    South San Francisco, CA, 94080 (US)
  • UBAS, Airol Anne
    South San Francisco, CA, 94080 (US)

(74) Representative: Mewburn Ellis LLP 
Aurora Building Counterslip
Bristol BS1 6BX
Bristol BS1 6BX (GB)

   


(54) MEK INHIBITORS, ALONE OR IN COMBINATION WITH CDK4/5 INHIBITORS, FOR USE IN TREATING CANCER