(19)
(11) EP 4 798 201 A1

(12)

(43) Date of publication:
02.09.2026 Bulletin 2026/36

(21) Application number: 24801803.8

(22) Date of filing: 24.10.2024
(51) International Patent Classification (IPC): 
A61K 31/47(2006.01)
A61P 35/00(2006.01)
C07K 16/28(2006.01)
A61K 45/06(2006.01)
A61P 35/04(2006.01)
(52) Cooperative Patent Classification (CPC):
A61K 45/06; A61P 35/00; A61P 35/04; A61K 31/47; C07K 16/2818; A61K 39/395
 
C-Sets:
  1. A61K 31/47, A61K 2300/00;
  2. A61K 39/395, A61K 2300/00;

(86) International application number:
PCT/US2024/052723
(87) International publication number:
WO 2025/090706 (01.05.2025 Gazette 2025/18)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
GE KH MA MD TN

(30) Priority: 27.10.2023 US 202363546013 P

(71) Applicant: Flare Therapeutics Inc.
Cambridge, MA 02139 (US)

(72) Inventors:
  • GJINI, Evisa
    Cambridge, MA 02142 (US)
  • MERTZ, Jennifer, Andrea
    Medford, MA 02155 (US)
  • WILSON, Jonathan, E.
    Arlington, MA 02474 (US)

(74) Representative: Potter Clarkson 
Chapel Quarter Mount Street
Nottingham NG1 6HQ
Nottingham NG1 6HQ (GB)

   


(54) PPARG INVERSE AGONISTS AND IMMUNOTHERAPIES FOR TREATING CANCER