(19)
(11) EP 4 798 207 A1

(12)

(43) Date of publication:
02.09.2026 Bulletin 2026/36

(21) Application number: 24808430.3

(22) Date of filing: 23.10.2024
(51) International Patent Classification (IPC): 
A61K 31/519(2006.01)
A61K 31/713(2006.01)
A61P 21/00(2006.01)
 A61K 31/7105(2006.01)
A61K 45/06(2006.01)
A61P 25/28(2006.01)
(52) Cooperative Patent Classification (CPC):
A61P 21/00; A61P 25/28; A61K 31/713; A61K 31/7105; A61K 31/519; A61K 45/06
 
C-Sets:
  1. A61K 31/519, A61K 2300/00;
  2. A61K 31/713, A61K 2300/00;
  3. A61K 31/7105, A61K 2300/00;
(86) International application number:
PCT/IB2024/060428
(87) International publication number:
WO 2025/088514 (01.05.2025 Gazette 2025/18)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
GE KH MA MD TN

(30) Priority: 24.10.2023 IT 202300022302

(71) Applicants:
  • Universita' Degli Studi di Roma "La Sapienza"
    00185 Roma (RM) (IT)
  • Fondazione Istituto Italiano di Tecnologia
    16163 Genova (GE) (IT)

(72) Inventors:
  • BOZZONI, Irene
    00185 Roma (RM) (IT)
  • DI TIMOTEO, Gaia
    00185 Roma (RM) (IT)
  • GIULIANI, Andrea
    00185 Roma (RM) (IT)
  • SETTI, Adriano
    00185 Roma (RM) (IT)

(74) Representative: Primiceri, Maria Vittoria et al
Praxi Intellectual Property S.p.A. Via Leonida Bissolati, 20
00187 Roma
00187 Roma (IT)

   


(54) METTL3-METTL14-COMPLEX INHIBITORS FOR THE TREATMENT OF NEUROMUSCULAR DEGENERATIVE PATHOLOGIES CAUSED BY OR LINKED TO MUTATIONS IN THE FUS GENE