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(11)

EP 4 798 214 A1

(12)

(43) Date of publication: 02.09.2026 Bulletin 2026/36 (21) Application number: 24881756.1 (22) Date of filing: 25.10.2024

(51) International Patent Classification (IPC):  A61K 31/7088(2006.01) A61K 47/54(2017.01) C12N 15/11(2006.01) A61P 1/16(2006.01) (52) Cooperative Patent Classification (CPC): A61P 1/16; A61K 31/713; C12N 2310/14; C12N 15/113; C12N 15/111; C12N 2310/351; C12N 2310/315; C12N 2320/32; A61K 47/545   C-Sets: C12N 2310/321, C12N 2310/3521; C12N 2310/322, C12N 2310/3533; (86) International application number: PCT/CN2024/127432 (87) International publication number: WO 2025/087397 (01.05.2025 Gazette 2025/18)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 25.10.2023 CN 202311396697 07.04.2024 CN 202410412449 20.09.2024 CN 202411321783 (71) Applicant: Rona Bioscience, Limited Admiralty, Hong Kong (HK)	(72) Inventors: HUANG, Jinyu Shanghai 201315 (CN) ZOU, Hao Shanghai 201315 (CN) PAN, Ling Shanghai 201315 (CN) YE, Piao Shanghai 201315 (CN) YANG, Xiaoyan Shanghai 201315 (CN) CAI, Guoqing Shanghai 201315 (CN) (74) Representative: Maiwald GmbH  Elisenhof Elisenstraße 3 80335 München 80335 München (DE)