(19)

(11)

EP 4 798 219 A1

(12)

(43) Date of publication: 02.09.2026 Bulletin 2026/36 (21) Application number: 24883337.8 (22) Date of filing: 24.10.2024

(51) International Patent Classification (IPC):  A61K 35/545(2015.01) A61P 25/00(2006.01) A61K 9/08(2006.01) A61B 5/11(2006.01) (52) Cooperative Patent Classification (CPC): A61P 25/00; A61K 9/0043; A61K 9/0085; A61B 5/369; A61B 5/165; A61B 5/4848; A61B 5/0215; A61B 5/0071; C12N 5/0623; C12N 2500/34; C12N 2533/52; C12N 2533/32; C12N 2501/115; C12N 2501/11; C12N 2501/415; C12N 5/0667; C12N 2501/01; C12N 2501/135; C12N 2501/13; A61K 35/30 (86) International application number: PCT/US2024/052831 (87) International publication number: WO 2025/090778 (01.05.2025 Gazette 2025/18)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 24.10.2023 US 202363545438 P 25.09.2024 US 202463698996 P (71) Applicant: University of Maryland, Baltimore Baltimore, MD 21201 (US)	(72) Inventor: JIA, Xiaofeng Baltimore, MD 21201 (US) (74) Representative: Schwarz & Partner Patentanwälte GmbH  Patentanwälte Wipplingerstraße 30 1010 Wien 1010 Wien (AT)