(19)

(11)

EP 4 798 223 A2

(12)

(88) Date of publication A3: 12.06.2025 (43) Date of publication: 02.09.2026 Bulletin 2026/36 (21) Application number: 24883408.7 (22) Date of filing: 25.10.2024

(51) International Patent Classification (IPC):  A61K 38/17(2006.01) C12N 15/86(2006.01) C07K 14/71(2006.01) (52) Cooperative Patent Classification (CPC): C12N 2770/36143; A61K 48/0016; A61K 48/0041; C12N 15/88; C07K 14/71 (86) International application number: PCT/US2024/052996 (87) International publication number: WO 2025/090889 (01.05.2025 Gazette 2025/18)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 27.10.2023 US 202363593800 P (71) Applicant: Replicate Bioscience, Inc. San Diego, CA 92121 (US)	(72) Inventors: WANG, Nathaniel Stephen San Diego, California 92121 (US) MAINE, Christian San Diego, California 92121 (US) ALIAHMAD, Parinaz San Diego, California 92121 (US) MIYAKE-STONER, Shigeki Joseph San Diego, California 92121 (US) (74) Representative: J A Kemp LLP  80 Turnmill Street London EC1M 5QU London EC1M 5QU (GB)