(19)
(11) EP 4 798 224 A1

(12)

(43) Date of publication:
02.09.2026 Bulletin 2026/36

(21) Application number: 24883500.1

(22) Date of filing: 28.10.2024
(51) International Patent Classification (IPC): 
A61K 38/18(2006.01)
A61K 39/395(2006.01)
C07K 14/48(2006.01)
 A61K 9/00(2006.01)
A61P 27/02(2006.01)
C07K 16/22(2006.01)
(52) Cooperative Patent Classification (CPC):
A61P 27/02; C07K 14/48; C07K 16/22; C07K 2317/76; A61K 2039/505; A61K 9/0014; A61K 9/0048; C07K 14/71; A61K 38/185; A61K 38/06; A61K 31/195; A61K 31/522; A61K 45/06
 
C-Sets:
  1. A61K 31/522, A61K 2300/00;
  2. A61K 38/185, A61K 2300/00;
  3. A61K 38/06, A61K 2300/00;
(86) International application number:
PCT/US2024/053226
(87) International publication number:
WO 2025/091016 (01.05.2025 Gazette 2025/18)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
GE KH MA MD TN

(30) Priority: 26.10.2023 US 202363593283 P

(71) Applicant: Indiana University Research & Technology Corporation
Bloomington IN 47405 (US)

(72) Inventors:
  • FEINBERG, Konstantin
    Indianapolis, Indiana 46204 (US)
  • BORSCHEL, Gregory H.
    Indianapolis, Indiana 46204 (US)

(74) Representative: Boult Wade Tennant LLP 
Salisbury Square House 8 Salisbury Square
London EC4Y 8AP
London EC4Y 8AP (GB)

   


(54) COMPOSITIONS COMPRISING P75NTR INHIBITORS AND RECOMBINANT NERVE GROWTH FACTOR AND METHODS FOR THE TREATMENT OF CORNEAL DISEASES AND DISORDERS USING THE SAME