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EP 4 798 232 A1

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(43) Date of publication: 02.09.2026 Bulletin 2026/36 (21) Application number: 24883194.3 (22) Date of filing: 22.10.2024

(51) International Patent Classification (IPC):  A61K 39/02(2006.01) A61K 39/385(2006.01) A61P 31/04(2006.01) C07K 14/25(2006.01) A61K 38/04(2006.01) C07H 21/04(2006.01) (52) Cooperative Patent Classification (CPC): A61P 31/04; C07K 14/25; A61K 2039/54; A61K 2039/545; A61K 39/0283; A61K 2039/575; A61K 2239/39; A61K 2039/55594; Y02A 50/30 (86) International application number: PCT/US2024/052421 (87) International publication number: WO 2025/090513 (01.05.2025 Gazette 2025/18)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 24.10.2023 US 202363545473 P (71) Applicants: VAXCYTE, INC. San Carlos, California 94070 (US) University Of Maryland, Baltimore Baltimore, Maryland 21201 (US)

(72) Inventors: FAIRMAN, Jeff San Carlos, California 94070 (US) KAPOOR, Neeraj San Carlos, California 94070 (US) TAMILSELVI, Chitradevi Sekar Baltimore, Maryland 21201 (US) TAREKEGN, Girmay Desalegn Baltimore, Maryland 21201 (US) PASETTI, Marcela F. Baltimore, Maryland 21201 (US) (74) Representative: Carpmaels & Ransford LLP  One Southampton Row London WC1B 5HA London WC1B 5HA (GB)