(19)
(11) EP 4 798 241 A1

(12)

(43) Date of publication:
02.09.2026 Bulletin 2026/36

(21) Application number: 24883474.9

(22) Date of filing: 26.10.2024
(51) International Patent Classification (IPC): 
A61K 40/31(2025.01)
C07K 14/705(2006.01)
C12N 15/62(2006.01)
A61P 35/00(2006.01)
 A61K 38/17(2006.01)
C07K 16/18(2006.01)
A61K 39/00(2006.01)
(52) Cooperative Patent Classification (CPC):
A61K 40/31; A61P 35/00; C07K 16/18; A61K 40/11; C07K 2317/622; A61K 40/42; A61K 40/428; A61K 2239/59; A61K 2239/13; A61K 2239/50; A61K 2239/55; A61K 45/06; C07K 14/7051; C07K 2319/03; C07K 16/44; C07K 2317/21; C07K 2317/77
(86) International application number:
PCT/US2024/053144
(87) International publication number:
WO 2025/090985 (01.05.2025 Gazette 2025/18)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
GE KH MA MD TN

(30) Priority: 27.10.2023 US 202363546043 P
04.10.2024 US 202463703742 P

(71) Applicant: Duke University
Durham, NC 27705 (US)

(72) Inventors:
  • CONEJO-GARCIA, Jose
    Durham, North Carolina 27705 (US)
  • ANTONIA, Scott
    Durham, North Carolina 27705 (US)

(74) Representative: Harris, Oliver John Richard 
Novagraaf UK Centrum Norwich Research Park Colney Lane
Norwich NR4 7UG
Norwich NR4 7UG (GB)

   


(54) COMPOSITIONS COMPRISING CHIMERIC ANTIGEN RECEPTORS TARGETING CITRULLINATED VIMENTIN AND METHODS OF USE THEREOF