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EP 4 798 243 A1

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(43) Date of publication: 02.09.2026 Bulletin 2026/36 (21) Application number: 24883410.3 (22) Date of filing: 25.10.2024

(51) International Patent Classification (IPC):  A61K 47/42(2017.01) A61K 8/64(2006.01) A61K 38/00(2006.01) A61P 35/00(2006.01) C12N 15/87(2006.01) A61K 8/60(2006.01) A61K 31/713(2006.01) A61K 48/00(2006.01) C12N 15/62(2006.01) (52) Cooperative Patent Classification (CPC): A61K 31/713; A61P 35/00; C12N 15/85; C12N 2810/10; A61K 48/0016; A61K 48/0041; C07K 2319/07; C07K 2319/10; A61K 47/64; A61K 47/6455 (86) International application number: PCT/US2024/052998 (87) International publication number: WO 2025/090891 (01.05.2025 Gazette 2025/18)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 26.10.2023 US 202363593270 P (71) Applicants: MUSC Foundation for Research Development Charleston, SC 29425 (US) U.S. Department of Veterans Affairs Washington, DC 20420 (US)

(72) Inventors: WILSON, Kyrie Pickens, SC 29671 (US) ROHRER, Bärbel Charleston, SC 29401 (US) JAKYMIW, Andrew Charleston, SC 29412 (US) HOLJENCIN, Charles Summerville, SC 29485 (US) (74) Representative: Leonard, Thomas Charles  Kilburn & Strode LLP Lacon London 84 Theobalds Road London WC1X 8NL London WC1X 8NL (GB)