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EP 4 798 247 A1

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(43) Date of publication: 02.09.2026 Bulletin 2026/36 (21) Application number: 24808421.2 (22) Date of filing: 23.10.2024

(51) International Patent Classification (IPC):  A61K 47/68(2017.01) A61P 35/00(2006.01) (52) Cooperative Patent Classification (CPC): A61K 47/68037; A61K 47/6851; A61K 47/6855; A61P 35/00; C07K 16/2818; C07K 16/30; C07K 16/32; A61K 2039/505; A61K 2039/507; C07K 16/2803; C07K 2317/31; C07K 2317/73 (86) International application number: PCT/IB2024/060392 (87) International publication number: WO 2025/088496 (01.05.2025 Gazette 2025/18)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 24.10.2023 US 202363545492 P (71) Applicants: AstraZeneca UK Limited Cambridge Biomedical Campus Cambridge CB2 0AA (GB) Daiichi Sankyo Company, Limited Tokyo 103-8426 (JP)

(72) Inventors: SUNG, Matthew Simon Wilmington, Delaware 19850-5437 (US) OMAR, Bilal Wilmington, Delaware 19850-5437 (US) CLANCY-THOMPSON, Eleanor Wilmington, Delaware 19850-5437 (US) METTETAL II, Jerome Thomas Wilmington, Delaware 19850-5437 (US) (74) Representative: Marks & Clerk LLP  15 Fetter Lane London EC4A 1BW London EC4A 1BW (GB)