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(11)

EP 4 798 250 A1

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(43) Date of publication: 02.09.2026 Bulletin 2026/36 (21) Application number: 24883029.1 (22) Date of filing: 12.04.2024

(51) International Patent Classification (IPC):  A61K 47/68(2017.01) C07K 14/47(2006.01) A61K 38/00(2006.01) A61P 35/00(2006.01) C07K 16/44(2006.01) A61K 47/65(2017.01) (52) Cooperative Patent Classification (CPC): A61P 35/00; C07K 16/44; C07K 2317/77; C07K 2317/92; C07K 2317/24; C07K 2317/73; C07K 2319/00; C07K 2319/10; C12N 9/222; C12N 9/22; A61K 47/68031; A61K 47/6843; A61K 47/6889; A61K 38/55 (86) International application number: PCT/US2024/024285 (87) International publication number: WO 2025/090121 (01.05.2025 Gazette 2025/18)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 27.10.2023 US 202363593747 P (71) Applicants: Yale University New Haven, CT 06510 (US) Nucleus Therapeutics Pty. Ltd. South Melbourne, Victoria 3205 (AU)	(72) Inventors: HANSEN, James New Haven, Connecticut 06510 (US) CAO, Fei New Haven, Connecticut 06510 (US) DUBLJEVIC, Valentina Melbourne, Victoria 3205 (AU) CAMPBELL, James Melbourne, Victoria 3205 (AU) (74) Representative: Boult Wade Tennant LLP  Salisbury Square House 8 Salisbury Square London EC4Y 8AP London EC4Y 8AP (GB)