(19)

(11)

EP 4 798 251 A1

(12)

(43) Date of publication: 02.09.2026 Bulletin 2026/36 (21) Application number: 24883220.6 (22) Date of filing: 23.10.2024

(51) International Patent Classification (IPC):  A61K 47/68(2017.01) C12N 15/864(2006.01) A61K 9/127(2025.01) A61P 25/28(2006.01) C07K 16/22(2006.01) A61K 47/69(2017.01) C12N 15/113(2010.01) A61K 47/54(2017.01) A61K 9/51(2006.01) A61P 27/02(2006.01) C12N 15/11(2006.01) (52) Cooperative Patent Classification (CPC): A61K 9/127; A61P 27/02; A61P 25/28; C12N 2750/14143; C12N 2750/14145; C12N 2810/859; C12N 2830/003; C12N 2510/00; C07K 16/28; A61K 47/6849; A61K 47/6851; A61K 47/6807 (86) International application number: PCT/US2024/052497 (87) International publication number: WO 2025/090565 (01.05.2025 Gazette 2025/18)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 23.10.2023 US 202363592353 P (71) Applicants: The Children's Medical Center Corporation Boston, MA 02115 (US) The United States Government as Represented by the Department of Veterans Affairs Washington, DC 20420 (US)

(72) Inventors: FRANK, Natasha Y. Cambridge, MA 02138 (US) FRANK, Markus H. Cambridge, MA 02138 (US) WILSON, Brian Cambridge, MA 02115 (US) FRANK, Alexander New York, NY 10128 (US) (74) Representative: Potter Clarkson  Chapel Quarter Mount Street Nottingham NG1 6HQ Nottingham NG1 6HQ (GB)