(19)

(11)

EP 4 798 253 A1

(12)

(43) Date of publication: 02.09.2026 Bulletin 2026/36 (21) Application number: 24883241.2 (22) Date of filing: 23.10.2024

(51) International Patent Classification (IPC):  A61K 48/00(2006.01) C07K 14/005(2006.01) C12N 7/00(2006.01) A61P 25/28(2006.01) C12N 15/86(2006.01) C12N 9/64(2006.01) (52) Cooperative Patent Classification (CPC): A61P 25/28; C07K 14/005; C12N 15/86; C12N 2750/14145; C12N 2750/14143; C12N 2810/40; C12N 2750/14122; A01K 2227/105; A01K 2217/075; C12N 9/485 (86) International application number: PCT/US2024/052555 (87) International publication number: WO 2025/090598 (01.05.2025 Gazette 2025/18)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 23.10.2023 US 202363592318 P (71) Applicant: The Children's Hospital of Philadelphia Philadelphia, PA 19104 (US)	(72) Inventors: RANUM, Paul T. Philadelphia, Pennsylvania 19104 (US) DAVIDSON, Beverly L. Philadelphia, Pennsylvania 19104 (US) KEISER, Megan S. Philadelphia, Pennsylvania 19106 (US) CHEN, Yonghong Philadelphia, Pennsylvania 19104 (US) TECEDOR, Luis Philadelphia, Pennsylvania 19104 (US) (74) Representative: Potter Clarkson  Chapel Quarter Mount Street Nottingham NG1 6HQ Nottingham NG1 6HQ (GB)