(19)

(11)

EP 4 798 254 A1

(12)

(43) Date of publication: 02.09.2026 Bulletin 2026/36 (21) Application number: 24883447.5 (22) Date of filing: 25.10.2024

(51) International Patent Classification (IPC):  A61K 48/00(2006.01) C07H 21/04(2006.01) C12N 15/00(2006.01) C07K 14/00(2006.01) (52) Cooperative Patent Classification (CPC): C12N 15/86; C12N 2750/14143; A61K 48/005; A61P 1/00; C12N 9/0014; C12Y 104/04002 (86) International application number: PCT/US2024/053073 (87) International publication number: WO 2025/090942 (01.05.2025 Gazette 2025/18)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 26.10.2023 US 202363593346 P (71) Applicant: University of Notre Dame du Lac South Bend, IN 46617 (US)

(72) Inventors: HALDAR, Kasturi South Bend, Indiana 46617 (US) PADMANABHAN, Prasad South Bend, Indiana 46617 (US) ALAM, Md. Suhail South Bend, Indiana 46617 (US) BALI, Adviti South Bend, Indiana 46617 (US) LOPEZ RAMIREZ, Alejandro South Bend, Indiana 46617 (US) CALHOUN, Shaun South Bend, Indiana 46617 (US) BICKERTON, Caroline South Bend, Indiana 46617 (US) (74) Representative: FRKelly  Waterways House Grand Canal Quay Dublin D02 PD39 Dublin D02 PD39 (IE)