(19)

(11)

EP 4 798 255 A1

(12)

(43) Date of publication: 02.09.2026 Bulletin 2026/36 (21) Application number: 24883508.4 (22) Date of filing: 28.10.2024

(51) International Patent Classification (IPC):  A61K 48/00(2006.01) C12N 15/86(2006.01) C07K 14/47(2006.01) (52) Cooperative Patent Classification (CPC): C12N 15/86; C12N 2750/14143; C12N 2830/48; C12N 2830/50; C12N 2830/007; C12N 2830/008; A61K 48/005; A61K 48/0058; C12N 15/85; C12N 2800/22; A61K 48/0075; A61K 38/00; C12N 9/80; C12Y 305/01 (86) International application number: PCT/US2024/053243 (87) International publication number: WO 2025/091025 (01.05.2025 Gazette 2025/18)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 26.10.2023 US 202363593435 P (71) Applicant: The Trustees of the University of Pennsylvania Philadelphia, PA 19104-4310 (US)	(72) Inventors: BENNETT, Jean Bryn Mawr, PA 19010 (US) SUN, Junwei Philadelphia, PA 19147 (US) SHINDLER, Kenneth Havertown, PA 19083 (US) MCDOUGALD, Devin Philadelphia, PA 19146 (US) GIBBONS ROSS, Ahmara Philadelphia, PA 19129 (US) (74) Representative: Appleyard Lees IP LLP  G Mill Dean Clough Industrial Park Halifax HX3 5AH Halifax HX3 5AH (GB)