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EP 4 798 257 A1

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(43) Date of publication: 02.09.2026 Bulletin 2026/36 (21) Application number: 24795190.8 (22) Date of filing: 25.10.2024

(51) International Patent Classification (IPC):  A61K 51/04(2006.01) C07B 59/00(2006.01) A61P 35/00(2006.01) A61K 103/30(2006.01) (52) Cooperative Patent Classification (CPC): A61K 51/0497; A61K 51/0402; A61P 35/00; C07B 59/002 (86) International application number: PCT/EP2024/080276 (87) International publication number: WO 2025/088147 (01.05.2025 Gazette 2025/18)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 27.10.2023 EP 23206467 (71) Applicant: Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts 69120 Heidelberg (DE)

(72) Inventors: SCHÄFER, Martin 69239 Neckarsteinach (DE) BAUDER-WUEST, Ulrike 69198 Schriesheim (DE) ROSCHER, Mareike 68165 Mannheim (DE) REMDE, Yvonne 69214 Eppelheim (DE) BENESOVÁ-SCHÄFER, Martina 69239 Neckarsteinach (DE) BARINKA, Cyril 19016 Prag (CZ) KUTILOVÁ, Zsófia 16000 Prag (CZ) MOTLOVÁ, Lucia 14000 Prag (CZ) (74) Representative: Altmann Stößel Dick Patentanwälte PartG mbB  Theodor-Heuss-Anlage 2 68165 Mannheim 68165 Mannheim (DE)