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(11)

EP 4 798 265 A1

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(43) Date of publication: 02.09.2026 Bulletin 2026/36 (21) Application number: 24805313.4 (22) Date of filing: 25.10.2024

(51) International Patent Classification (IPC):  A61M 1/00(2006.01) A61M 5/168(2006.01) A61M 5/142(2006.01) (52) Cooperative Patent Classification (CPC): A61M 1/73; A61M 1/71; A61M 5/16881; A61M 5/14248; A61M 2209/088; A61M 2202/0464; A61M 2005/14268 (86) International application number: PCT/US2024/053050 (87) International publication number: WO 2025/090925 (01.05.2025 Gazette 2025/18)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 25.10.2023 US 202363545566 P (71) Applicant: The Cleveland Clinic Foundation Cleveland, OH 44195 (US)	(72) Inventors: NAGEL, Sean Cleveland Heights, OH 44106 (US) SAMOREZOV, Sergey Highland Heights, OH 44143 (US) OZ, Tal 3885700 Kibbutz Hamaapil (IL) YEDGAR, Aviad 6228823 Tel Aviv (IL) KAHLON, Yaakov 4410202 Kefar Sava (IL) (74) Representative: A.P.I. Conseil  Technopôle Hélioparc 4, rue Jules Ferry 64000 Pau 64000 Pau (FR)