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EP 4 798 306 A1

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(43) Date of publication: 02.09.2026 Bulletin 2026/36 (21) Application number: 24801689.1 (22) Date of filing: 25.10.2024

(51) International Patent Classification (IPC):  A61P 25/28(2006.01) C07D 487/04(2006.01) C07D 493/04(2006.01) C07D 498/04(2006.01) C07D 471/04(2006.01) C07D 487/10(2006.01) C07D 493/10(2006.01) C07D 513/04(2006.01) (52) Cooperative Patent Classification (CPC): C07D 471/04; C07D 487/04; C07D 513/04; C07D 498/04; C07D 493/10; C07D 493/04; C07D 487/10; A61P 25/28; A61P 9/00; A61P 19/08; A61P 21/00 (86) International application number: PCT/JP2024/038053 (87) International publication number: WO 2025/089370 (01.05.2025 Gazette 2025/18)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 26.10.2023 WO PCT/JP2023/038720 (71) Applicant: Otsuka Pharmaceutical Co., Ltd. Tokyo 101-8535 (JP)

(72) Inventors: SUZUKI, Masaki Osaka-shi, Osaka 540-0021 (JP) BERDINI, Valerio Cambridge Science Park, Milton Road, Cambridge CB4 0QA (GB) YUKI, Yohei Osaka-shi, Osaka 540-0021 (JP) TAMANINI, Emiliano Cambridge Science Park, Milton Road, Cambridge CB4 0QA (GB) IIDA, Masatoshi Osaka-shi, Osaka 540-0021 (JP) WALSH, Louise Marie Cambridge Science Park, Milton Road, Cambridge CB4 0QA (GB) SOMEYA, Hidenori Osaka-shi, Osaka 540-0021 (JP) OSBORNE, James Daniel Cambridge Science Park, Milton Road, Cambridge CB4 0QA (GB) FUJIWARA, Hideto Osaka-shi, Osaka 540-0021 (JP) (74) Representative: Hoffmann Eitle  Patent- und Rechtsanwälte PartmbB Arabellastraße 30 81925 München 81925 München (DE)