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EP 4 798 357 A1

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(43) Date of publication: 02.09.2026 Bulletin 2026/36 (21) Application number: 24808396.6 (22) Date of filing: 06.11.2024

(51) International Patent Classification (IPC):  B01F 23/213(2022.01) B01F 25/433(2022.01) B01F 23/45(2022.01) B01F 33/30(2022.01) (52) Cooperative Patent Classification (CPC): B01F 23/45; B01F 23/21321; B01F 33/3045; B01F 33/305; B01F 25/4331 (86) International application number: PCT/GB2024/052808 (87) International publication number: WO 2025/099415 (15.05.2025 Gazette 2025/20)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 07.11.2023 GB 202317080 07.11.2023 GB 202317079 (71) Applicant: The Francis Crick Institute Limited London NW1 1AT (GB)	(72) Inventors: ENCHEV, Radoslav Ivanov London NW1 1AT (GB) MÄEOTS, Märt-Erik London NW1 1AT (GB) WALBRAN, Matthew Philip Auckland (NZ) ESFAHANI, Mohammad Mehdi Nasr London W12 7TA (GB) (74) Representative: Cousens, Nico et al Kilburn & Strode LLP Lacon London 84 Theobalds Road London WC1X 8NL London WC1X 8NL (GB)