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EP 4 798 576 A1

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(43) Date of publication: 02.09.2026 Bulletin 2026/36 (21) Application number: 24883173.7 (22) Date of filing: 22.10.2024

(51) International Patent Classification (IPC):  C07D 401/12(2006.01) A61K 31/454(2006.01) A61K 31/4453(2006.01) C07D 295/26(2006.01) A61K 31/4545(2006.01) A61P 35/00(2006.01) (52) Cooperative Patent Classification (CPC): A61K 31/454; A61K 31/4453; A61P 35/00; C07D 295/26; C07D 209/30; C07D 209/08; C07D 235/06 (86) International application number: PCT/US2024/052354 (87) International publication number: WO 2025/090460 (01.05.2025 Gazette 2025/18)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 23.10.2023 US 202363545263 P (71) Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA Oakland, CA 94607-5200 (US)	(72) Inventors: JUNG, Michael, E. Los Angeles, CA 90095-7191 (US) PAJONK, Frank Los Angeles, CA 90095-7191 (US) HE, Ling Los Angeles, CA 90095-7191 (US) CHEN, Xiaohong Los Angeles, CA 90095-7191 (US) DING, Hui Los Angeles, CA 90095-7191 (US) (74) Representative: Vossius & Partner Patentanwälte Rechtsanwälte mbB  Siebertstraße 3 81675 München 81675 München (DE)