(19)

(11)

EP 4 798 578 A1

(12)

(43) Date of publication: 02.09.2026 Bulletin 2026/36 (21) Application number: 24804650.0 (22) Date of filing: 23.10.2024

(51) International Patent Classification (IPC):  C07D 401/14(2006.01) A61K 31/495(2006.01) A61P 35/00(2006.01) (52) Cooperative Patent Classification (CPC): C07D 401/14; A61P 35/00 (86) International application number: PCT/US2024/052612 (87) International publication number: WO 2025/090640 (01.05.2025 Gazette 2025/18)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 23.10.2023 US 202363592434 P (71) Applicant: Volastra Therapeutics, Inc. New York, NY 10027 (US)	(72) Inventors: MAO, Jianmin New York, New York 10027 (US) SU, Michael New York, New York 10027 (US) COGAN, Derek A. New York, New York 10027 (US) ZHANG, Rumin New York, New York 10027 (US) DRUTMAN, Scott New York, New York 10027 (US) (74) Representative: Mewburn Ellis LLP  Aurora Building Counterslip Bristol BS1 6BX Bristol BS1 6BX (GB)