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EP 4 798 579 A1

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(43) Date of publication: 02.09.2026 Bulletin 2026/36 (21) Application number: 24883195.0 (22) Date of filing: 22.10.2024

(51) International Patent Classification (IPC):  C07D 403/12(2006.01) A61K 31/416(2006.01) A61K 31/437(2006.01) A61K 31/4709(2006.01) A61K 31/4985(2006.01) A61K 31/517(2006.01) A61K 31/55(2006.01) C07D 217/24(2006.01) C07D 403/14(2006.01) C07D 417/12(2006.01) A61K 31/403(2006.01) A61K 31/4162(2006.01) A61K 31/454(2006.01) A61K 31/4725(2006.01) A61K 31/502(2006.01) A61K 31/519(2006.01) A61P 25/28(2006.01) C07D 401/12(2006.01) C07D 405/14(2006.01) C07D 471/04(2006.01) (52) Cooperative Patent Classification (CPC): C07D 403/14; C07D 401/12; C07D 217/24; C07D 405/14; C07D 403/12; C07D 471/04; C07D 417/12; C07D 401/14; C07D 413/14 (86) International application number: PCT/US2024/052422 (87) International publication number: WO 2025/090514 (01.05.2025 Gazette 2025/18)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 23.10.2023 US 202363592477 P 11.10.2024 US 202463706556 P (71) Applicant: Nura Bio, Inc. South San Francisco, CA 94080 (US)

(72) Inventors: MEDINA, Julio C. San Francisco, California 94080 (US) SINGHA ROY, Moumita San Francisco, California 94080 (US) LI, Guo San Francisco, California 94080 (US) HU, Chaowei San Francisco, California 94080 (US) TEGLEY, Christopher Michael San Francisco, California 94080 (US) TASKER, Andrew Stewart San Francisco, California 94080 (US) REYNOLDS, Charles Howard San Francisco, California 94080 (US) (74) Representative: Mewburn Ellis LLP  Aurora Building Counterslip Bristol BS1 6BX Bristol BS1 6BX (GB)