(19)
(11) EP 4 798 580 A1

(12)

(43) Date of publication:
02.09.2026 Bulletin 2026/36

(21) Application number: 24801448.2

(22) Date of filing: 22.10.2024
(51) International Patent Classification (IPC): 
C07D 405/04(2006.01)
A61K 31/4375(2006.01)
C07D 471/04(2006.01)
A61P 25/04(2006.01)
(52) Cooperative Patent Classification (CPC):
C07D 471/04; C07D 405/04; A61P 25/04
(86) International application number:
PCT/US2024/052361
(87) International publication number:
WO 2025/090465 (01.05.2025 Gazette 2025/18)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
GE KH MA MD TN

(30) Priority: 23.10.2023 US 202363592362 P
24.10.2023 US 202363592698 P
08.05.2024 US 202463644192 P

(71) Applicant: Vertex Pharmaceuticals Incorporated
Boston, MA 02210 (US)

(72) Inventors:
  • MILLER, Mark Thomas
    Boston, MA 02210 (US)
  • PINDER, Joanne Louise
    Boston, MA 02210 (US)
  • KNEGTEL, Ronald Marcellus
    Boston, MA 02210 (US)
  • MUI, James Jun Bon
    Boston, MA 02210 (US)
  • BECK, Elizabeth Mary
    Boston, MA 02210 (US)
  • CHUDYK, Ewa Iwona
    Boston, MA 02210 (US)
  • SIMPSON, Iain
    Boston, MA 02210 (US)
  • SLOCHOWER, David Robert
    Boston, MA 02210 (US)
  • NEUBERT, Timothy Donald
    Boston, MA 02210 (US)
  • HURLEY, Dennis James
    Boston, MA 02210 (US)
  • SCHARF, Adam
    Boston, MA 02210 (US)
  • PATEL, Urvi
    Boston, MA 02210 (US)
  • HADIDA RUAH, Sara Sabina
    Boston, MA 02210 (US)
  • ZHOU, Jinglan
    Boston, MA 02210 (US)
  • GHIRMAI, Senait G.
    Boston, MA 02210 (US)
  • VALIULIN, Roman Askatovich
    Boston, MA 02210 (US)
  • WEBB, Peter
    Boston, MA 02210 (US)
  • AERTGEERTS, Kathleen
    Boston, MA 02210 (US)
  • KINTZER, Alexander Frederick
    Boston, MA 02210 (US)
  • CLEVELAND, Thomas
    Boston, MA 02210 (US)
  • CHAU, Jaclyn
    Boston, MA 02210 (US)
  • McCARTNEY, Jason
    Boston, MA 02210 (US)
  • STORCK, Pierre-Henri
    Boston, MA 02210 (US)

(74) Representative: Carpmaels & Ransford LLP 
One Southampton Row
London WC1B 5HA
London WC1B 5HA (GB)

   


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