(19)
(11) EP 4 798 581 A1

(12)

(43) Date of publication:
02.09.2026 Bulletin 2026/36

(21) Application number: 24802093.5

(22) Date of filing: 22.10.2024
(51) International Patent Classification (IPC): 
C07D 405/04(2006.01)
C07D 405/14(2006.01)
C07D 491/048(2006.01)
C07D 491/08(2006.01)
A61K 31/443(2006.01)
 A61P 25/04(2006.01)
C07D 413/14(2006.01)
C07D 491/052(2006.01)
C07D 495/04(2006.01)
(52) Cooperative Patent Classification (CPC):
C07D 405/04; C07D 413/14; C07D 491/052; C07D 405/14; C07D 495/04; C07D 491/08; C07D 491/048; A61P 25/04
(86) International application number:
PCT/US2024/052382
(87) International publication number:
WO 2025/090480 (01.05.2025 Gazette 2025/18)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
GE KH MA MD TN

(30) Priority: 23.10.2023 US 202363592371 P
24.10.2023 US 202363592715 P

(71) Applicant: Vertex Pharmaceuticals Incorporated
Boston, MA 02210 (US)

(72) Inventors:
  • MILLER, Mark, Thomas
    Boston, MA 02210 (US)
  • PINDER, Joanne, Louise
    Boston, MA 02210 (US)
  • KNEGTEL, Ronald, Marcellus
    Boston, MA 02210 (US)
  • MUI, James, Jun, Bon
    Boston, MA 02210 (US)
  • BECK, Elizabeth, Mary
    Boston, MA 02210 (US)
  • CHUDYK, Ewa, Iwona
    Boston, MA 02210 (US)
  • SIMPSON, Iain
    Boston, MA 02210 (US)
  • SLOCHOWER, David, Robert
    Boston, MA 02210 (US)
  • NEUBERT, Timothy, Donald
    Boston, MA 02210 (US)
  • HURLEY, Dennis, James
    Boston, MA 02210 (US)
  • SCHARF, Adam
    Boston, MA 02210 (US)
  • PATEL, Urvi
    Boston, MA 02210 (US)
  • HADIDA RUAH, Sara, Sabina
    Boston, MA 02210 (US)
  • ZHOU, Jinglan
    Boston, MA 02210 (US)
  • GHIRMAI, Senait, G.
    Boston, MA 02210 (US)
  • VALIULIN, Roman, Askatovich
    Boston, MA 02210 (US)
  • WEBB, Peter
    Boston, MA 02210 (US)
  • AERTGEERTS, Kathleen
    Boston, MA 02210 (US)
  • KINTZER, Alexander, Frederick
    Boston, MA 02210 (US)
  • CLEVELAND, Thomas
    Boston, MA 02210 (US)
  • CHAU, Jaclyn
    Boston, MA 02210 (US)
  • McCARTNEY, Jason
    Boston, MA 02210 (US)
  • JACQUES, Reece
    Boston, MA 02210 (US)
  • KEILLY, Shazia
    Boston, MA 02210 (US)
  • SALMAN, Alan, Alessandro
    Boston, MA 02210 (US)
  • AUSTIN, James, Robert
    Boston, MA 02210 (US)
  • SOUSA, Bruno, Artur
    Boston, MA 02210 (US)
  • PULLIN, Robert, David, Charles
    Boston, MA 02210 (US)
  • VOGEL, Carl, Victor
    Boston, MA 02210 (US)
  • DODD, James
    Boston, MA 02210 (US)
  • STORCK, Pierre-Henri
    Boston, MA 02210 (US)

(74) Representative: Carpmaels & Ransford LLP 
One Southampton Row
London WC1B 5HA
London WC1B 5HA (GB)

   


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