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EP 4 798 582 A1

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(43) Date of publication: 02.09.2026 Bulletin 2026/36 (21) Application number: 24883176.0 (22) Date of filing: 22.10.2024

(51) International Patent Classification (IPC):  C07D 405/12(2006.01) C07D 213/82(2006.01) C07D 405/14(2006.01) C07D 409/14(2006.01) A61P 25/00(2006.01) C07D 213/81(2006.01) C07D 409/12(2006.01) C07D 401/12(2006.01) A61K 31/443(2006.01) A61P 25/36(2006.01) (52) Cooperative Patent Classification (CPC): A61P 25/00; A61P 25/36; C07D 213/81; C07D 213/82; C07D 401/12; C07D 405/12; C07D 405/14; C07D 409/12; C07D 409/14; C07D 307/52; C07D 233/90 (86) International application number: PCT/US2024/052362 (87) International publication number: WO 2025/090466 (01.05.2025 Gazette 2025/18)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 25.10.2023 US 202363545636 P (71) Applicants: The University of North Carolina at Chapel Hill Chapel Hill, NC 27514 (US) University of Florida Research Foundation, Inc. (UFRF) Gainesville, FL 32611 (US)

(72) Inventors: AUBE, Jeffrey Pittsboro, NC 27312 (US) TAYLOR, Kimberly S. Chapel Hill, NC 27514 (US) BOHN, Laura Jupiter, FL 33458 (US) (74) Representative: Barker Brettell LLP  100 Hagley Road Edgbaston Birmingham, West Midlands B16 8QQ Birmingham, West Midlands B16 8QQ (GB)