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(11)

EP 4 798 586 A1

(12)

(43) Date of publication: 02.09.2026 Bulletin 2026/36 (21) Application number: 24802100.8 (22) Date of filing: 22.10.2024

(51) International Patent Classification (IPC):  C07D 471/04(2006.01) A61K 31/4375(2006.01) C07D 213/643(2006.01) A61P 25/04(2006.01) C07D 213/61(2006.01) C07F 1/00(2006.01) (52) Cooperative Patent Classification (CPC): C07D 471/04; A61P 25/04; C07D 213/643; C07D 213/61; C07F 5/025 (86) International application number: PCT/US2024/052419 (87) International publication number: WO 2025/090511 (01.05.2025 Gazette 2025/18)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 23.10.2023 US 202363592494 P 23.10.2023 US 202363592530 P (71) Applicant: Vertex Pharmaceuticals Incorporated Boston, MA 02210 (US)

(72) Inventors: PERESYPKIN, Andrey Boston, MA 02210 (US) WILDE, Nathan C. Boston, MA 02210 (US) LU, Jennifer Boston, MA 02210 (US) O'NEIL, Simon Adam Boston, MA 02210 (US) MEDEK, Ales Boston, MA 02210 (US) CHEN, Jiahui Boston, MA 02210 (US) GAGNON, Kevin James Boston, MA 02210 (US) ROEPER, Stefanie Boston, MA 02210 (US) STEPHENS, David E. Boston, MA 02210 (US) TSAY, Charlene Boston, MA 02210 (US) (74) Representative: Carpmaels & Ransford LLP  One Southampton Row London WC1B 5HA London WC1B 5HA (GB)