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EP 4 798 587 A1

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(43) Date of publication: 02.09.2026 Bulletin 2026/36 (21) Application number: 24802384.8 (22) Date of filing: 22.10.2024

(51) International Patent Classification (IPC):  C07D 471/04(2006.01) C07F 1/00(2006.01) A61P 25/04(2006.01) C07C 1/00(2006.01) A61K 31/4375(2006.01) (52) Cooperative Patent Classification (CPC): C07D 471/04; A61P 25/04; C07C 37/16; C07B 2200/13; C07C 309/65; C07C 309/73; C07C 305/26; C07C 307/02; C07F 5/025; C07F 7/1804   C-Sets: C07C 37/16, C07C 39/28; (86) International application number: PCT/US2024/052424 (87) International publication number: WO 2025/090516 (01.05.2025 Gazette 2025/18)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 23.10.2023 US 202363592556 P 23.10.2023 US 202363592507 P (71) Applicant: Vertex Pharmaceuticals Incorporated Boston, MA 02210 (US)

(72) Inventors: PERESYPKIN, Andrey Boston, MA 02210 (US) WILDE, Nathan, C. Boston, MA 02210 (US) LU, Jennifer Boston, MA 02210 (US) O'NEIL, Simon, Adam Boston, MA 02210 (US) MEDEK, Ales Boston, MA 02210 (US) GAGNON, Kevin, James Boston, MA 02210 (US) ROEPER, Stefanie Boston, MA 02210 (US) LAWS, Stephen, W. Boston, MA 02210 (US) MAULDIN, Dustin, Lee Boston, MA 02210 (US) ZENG, Xingzhong Boston, MA 02210 (US) TSAY, Charlene Boston, MA 02210 (US) BLIGH, Cavan, McKeon Boston, MA 02210 (US) WARZECHA, Monika Boston, MA 02210 (US) (74) Representative: Carpmaels & Ransford LLP  One Southampton Row London WC1B 5HA London WC1B 5HA (GB)