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(11)

EP 4 798 606 A1

(12)

(43) Date of publication: 02.09.2026 Bulletin 2026/36 (21) Application number: 24883285.9 (22) Date of filing: 23.10.2024

(51) International Patent Classification (IPC):  C07K 7/06(2006.01) C07K 16/00(2006.01) A61K 39/395(2006.01) C12N 15/85(2006.01) C07K 14/00(2006.01) A61K 38/16(2006.01) C12N 15/09(2006.01) A61P 35/00(2006.01) (52) Cooperative Patent Classification (CPC): A61P 35/00; C07K 16/00; C12N 15/85; C12N 15/88; A61K 48/005; C07K 2317/80; C12N 15/79; C07K 7/08; C07K 2319/04; C07K 2319/60; A61K 38/00 (86) International application number: PCT/US2024/052670 (87) International publication number: WO 2025/090679 (01.05.2025 Gazette 2025/18)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 23.10.2023 US 202363592479 P 01.12.2023 US 202363605403 P (71) Applicant: The Board of Regents of the University of Texas System Austin, Texas 78701 (US)	(72) Inventors: SIEGWART, Daniel J. Dallas, Texas 75390 (US) FARBIAK, Lukas Dallas, Texas 75390 (US) MILLER, William Dallas, Texas 75390 (US) (74) Representative: Potter Clarkson  Chapel Quarter Mount Street Nottingham NG1 6HQ Nottingham NG1 6HQ (GB)