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(11)

EP 4 798 609 A1

(12)

(43) Date of publication: 02.09.2026 Bulletin 2026/36 (21) Application number: 24883314.7 (22) Date of filing: 24.10.2024

(51) International Patent Classification (IPC):  C07K 14/005(2006.01) A61P 31/14(2006.01) A61K 39/215(2006.01) (52) Cooperative Patent Classification (CPC): C07K 14/005; A61P 31/14; C12N 2770/20034; C12N 2770/20022; A61K 39/12; A61K 2039/55555; A61K 2039/575; A61K 2039/54; A61K 2039/545; A61K 2039/57; A61K 2039/555 (86) International application number: PCT/US2024/052777 (87) International publication number: WO 2025/090742 (01.05.2025 Gazette 2025/18)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 26.10.2023 US 202363593422 P (71) Applicant: Duke University Durham, NC 27705 (US)	(72) Inventors: SAUNDERS, Kevin Durham, North Carolina 27705 (US) HAYNES, Barton F. Durham, North Carolina 27705 (US) YU, Jae-Sung Durham, North Carolina 27705 (US) LEE, Esther Durham, North Carolina 27705 (US) (74) Representative: Barker Brettell LLP  100 Hagley Road Edgbaston Birmingham, West Midlands B16 8QQ Birmingham, West Midlands B16 8QQ (GB)