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EP 4 798 615 A2

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(88) Date of publication A3: 12.06.2025 (43) Date of publication: 02.09.2026 Bulletin 2026/36 (21) Application number: 24809074.8 (22) Date of filing: 22.10.2024

(51) International Patent Classification (IPC):  C07K 14/72(2006.01) A61K 47/54(2017.01) A61K 38/00(2006.01) (52) Cooperative Patent Classification (CPC): C07K 14/72; A61K 38/00; A61K 47/542; A61K 47/65; C07K 14/61 (86) International application number: PCT/IL2024/051024 (87) International publication number: WO 2025/088605 (01.05.2025 Gazette 2025/18)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 24.10.2023 US 202363592760 P (71) Applicant: OPKO Biologics Ltd. Kiryat Gat, 8211804 (IL)	(72) Inventors: MOSCHCOVICH, Laura 5401844 Givat Shmuel (IL) RIVKIN, Amit 7401604 Nes Ziona (IL) BAR-ILAN, Ahuva 76812 Yad-Binyamin (IL) GOLAN, Moran 8532000 Kibutz Shoval (IL) GERZON-ZAKAR, Miri 70795 Kidron (IL) NEZNANSKY, Avi 4486400 Zur Igal (IL) (74) Representative: Pearl Cohen UK  The Gridiron Building One Pancras Square London N1C 4AG London N1C 4AG (GB)