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(11)

EP 4 798 617 A1

(12)

(43) Date of publication: 02.09.2026 Bulletin 2026/36 (21) Application number: 24805298.7 (22) Date of filing: 24.10.2024

(51) International Patent Classification (IPC):  C07K 16/00(2006.01) G01N 30/86(2006.01) G01N 30/02(2006.01) (52) Cooperative Patent Classification (CPC): C07K 16/00; C07K 2317/31; C07K 2317/52; C07K 2317/56; C07K 2317/622; G01N 30/8693; C40B 30/10; G01N 2500/04; G01N 2030/8831; G01N 30/96 (86) International application number: PCT/US2024/052797 (87) International publication number: WO 2025/090753 (01.05.2025 Gazette 2025/18)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 26.10.2023 US 202363545879 P (71) Applicant: Amgen Inc. Thousand Oaks, CA 91320-1799 (US)

(72) Inventors: PARTIN, Alexander Thousand Oaks, California 91320-1799 (US) MIRTS, Evan Neal Thousand Oaks, California 91320-1799 (US) GONG, Danyang Thousand Oaks, California 91320-1799 (US) RILEY, Timothy Patrick Thousand Oaks, California 91320-1799 (US) GARCES, Fernando Thousand Oaks, California 91320-1799 (US) (74) Representative: Lau, Sarah Jane  Kilburn & Strode LLP Lacon London 84 Theobalds Road London WC1X 8NL London WC1X 8NL (GB)