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(11)

EP 4 798 622 A1

(12)

(43) Date of publication: 02.09.2026 Bulletin 2026/36 (21) Application number: 24883382.4 (22) Date of filing: 25.10.2024

(51) International Patent Classification (IPC):  C07K 16/24(2006.01) A61K 38/04(2006.01) A61K 39/395(2006.01) C12N 5/10(2006.01) (52) Cooperative Patent Classification (CPC): C07K 16/241; C07K 2317/22; C07K 2317/569; C07K 2317/92; C07K 2317/76; C07K 2317/24 (86) International application number: PCT/US2024/052920 (87) International publication number: WO 2025/090840 (01.05.2025 Gazette 2025/18)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 27.10.2023 US 202363593885 P (71) Applicant: Rutgers, the State University of New Jersey New Brunswick, NJ 08901 (US)	(72) Inventors: D'ADAMIO, Luciano New Brunswick, New Jersey 08901 (US) YIN, Tao New Brunswick, New Jersey 08901 (US) (74) Representative: De Clercq & Partners  Edgard Gevaertdreef 10a 9830 Sint-Martens-Latem 9830 Sint-Martens-Latem (BE)