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EP 4 798 623 A1

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(43) Date of publication: 02.09.2026 Bulletin 2026/36 (21) Application number: 24794816.9 (22) Date of filing: 25.10.2024

(51) International Patent Classification (IPC):  C07K 16/28(2006.01) A61P 35/00(2006.01) A61K 47/68(2017.01) A61K 39/00(2006.01) (52) Cooperative Patent Classification (CPC): C07K 16/28; C07K 2317/24; A61K 2039/505; A61P 35/00; A61K 47/6849; C07K 2317/77; A61K 47/68031; A61K 47/6889; A61K 47/6877; G01N 2800/52; G01N 33/5753; G01N 33/5759; G01N 33/57557 (86) International application number: PCT/EP2024/080206 (87) International publication number: WO 2025/088105 (01.05.2025 Gazette 2025/18)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 27.10.2023 WO PCT/CN2023/127244 17.05.2024 WO PCT/CN2024/093861 (71) Applicants: Keymed Biosciences Co., Ltd Chengdu, Sichuan 610219 (CN) Lepu Biopharma Co., Ltd. Shanghai 201112 (CN)

(72) Inventors: CHEN, Bo Chengdu, Sichuan 610219 (CN) LIU, Wei Chengdu, Sichuan 610219 (CN) HU, Chaohong Shanghai 201203 (CN) (74) Representative: Mewburn Ellis LLP  Aurora Building Counterslip Bristol BS1 6BX Bristol BS1 6BX (GB)