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EP 4 798 626 A1

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(43) Date of publication: 02.09.2026 Bulletin 2026/36 (21) Application number: 24805312.6 (22) Date of filing: 25.10.2024

(51) International Patent Classification (IPC):  C07K 16/28(2006.01) C12N 15/113(2010.01) A61P 25/28(2006.01) C07K 16/40(2006.01) A61P 21/00(2006.01) (52) Cooperative Patent Classification (CPC): C07K 2317/33; C07K 2317/31; C07K 2317/35; C07K 2317/21; C07K 2317/41; C07K 2317/55; C07K 2317/64; C07K 2317/77; C07K 2317/92; C07K 2317/94; C07K 2317/34; A61K 2039/505; A61K 2039/545; C07K 16/40; C07K 16/2881; A61P 21/00; A61P 25/28; C12N 2310/3513; C12N 2310/11; C12N 2310/3231; C12N 2310/341; C12N 2310/14; C12N 15/113; C12N 15/1137 (86) International application number: PCT/US2024/053007 (87) International publication number: WO 2025/090898 (01.05.2025 Gazette 2025/18)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 26.10.2023 US 202363545848 P 02.02.2024 US 202463549055 P (71) Applicant: Biogen MA Inc. Cambridge, MA 02142 (US)

(72) Inventors: SMITH, Benjamin A. Cambridge, Massachusetts 02142 (US) ARNDT, Joseph Walter Cambridge, Massachusetts 02142 (US) JULIAN, Mark Christopher Cambridge, Massachusetts 02142 (US) KOKSAL, Adem Can Cambridge, Massachusetts 02142 (US) MEEKS, Caitlin Bryanna Cambridge, Massachusetts 02142 (US) CAMERON, Thomas O. Cambridge, Massachusetts 02142 (US) (74) Representative: J A Kemp LLP  80 Turnmill Street London EC1M 5QU London EC1M 5QU (GB)