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EP 4 798 627 A2

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(88) Date of publication A3: 12.06.2025 (43) Date of publication: 02.09.2026 Bulletin 2026/36 (21) Application number: 24883459.0 (22) Date of filing: 25.10.2024

(51) International Patent Classification (IPC):  C07K 16/28(2006.01) C12N 5/0783(2010.01) C07K 14/705(2006.01) A61P 35/00(2006.01) (52) Cooperative Patent Classification (CPC): A61K 35/17; A61K 35/545; C12N 5/0636; C12N 2510/00; C12N 2506/45; C12N 2506/02; A61K 40/11; A61K 40/32; A61P 35/00; C12N 2740/15043; A61K 40/4224; A61K 2239/31; A61K 2239/38 (86) International application number: PCT/US2024/053110 (87) International publication number: WO 2025/090961 (01.05.2025 Gazette 2025/18)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 27.10.2023 US 202363546111 P (71) Applicants: The Regents of the University of California Oakland, CA 94607 (US) Shinobi Therapeutics, Inc. South San Francisco, California 94080 (US)

(72) Inventors: DEUSE, Tobias Oakland, California 94607 (US) ZHENG, Yueting Fremont, California 94539 (US) (74) Representative: Bassil, Nicholas Charles et al Kilburn & Strode LLP Lacon London 84 Theobalds Road London WC1X 8NL London WC1X 8NL (GB)