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(11)

EP 4 798 631 A1

(12)

(43) Date of publication: 02.09.2026 Bulletin 2026/36 (21) Application number: 24880842.0 (22) Date of filing: 24.10.2024

(51) International Patent Classification (IPC):  C07K 19/00(2006.01) C07K 14/52(2006.01) C07K 16/00(2006.01) C12N 5/0783(2010.01) A61K 39/00(2006.01) C07K 14/705(2006.01) C12N 5/071(2010.01) (52) Cooperative Patent Classification (CPC): C07K 14/52; C07K 14/705; C07K 2319/30; C07K 14/47; C12N 5/0636; C12N 2501/26; C12N 2501/125 (86) International application number: PCT/CA2024/051405 (87) International publication number: WO 2025/086007 (01.05.2025 Gazette 2025/18)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 24.10.2023 US 202363592684 P (71) Applicant: Sunnybrook Research Institute Toronto, Ontario M4N 3M5 (CA)	(72) Inventors: ZUNIGA-PFLUCKER, Juan Carlos Toronto, Ontario M5H 0A6 (CA) MOHTASHAMI, Mahmood Toronto, Ontario M2N 1C8 (CA) (74) Representative: Script Intellectual Property LLP  Suite J, Anchor House School Close Chandlers Ford Eastleigh, Hampshire SO53 4DY Eastleigh, Hampshire SO53 4DY (GB)