(19)
(11) EP 4 798 698 A1

(12)

(43) Date of publication:
02.09.2026 Bulletin 2026/36

(21) Application number: 24901357.4

(22) Date of filing: 02.12.2024
(51) International Patent Classification (IPC): 
C12N 5/077(2010.01)
C12N 5/0786(2010.01)
 A61K 35/34(2015.01)
(52) Cooperative Patent Classification (CPC):
C12N 2506/02; C12N 2506/45; C12N 5/0657; C12N 2501/727; C12N 2501/155; C12N 2501/415; C12N 2502/1329; C12N 2502/1157; A61K 35/15
 
C-Sets:
  1. A61K 35/34, A61K 2300/00;
  2. A61K 35/15, A61K 2300/00;
(86) International application number:
PCT/US2024/058055
(87) International publication number:
WO 2025/122416 (12.06.2025 Gazette 2025/24)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
GE KH MA MD TN

(30) Priority: 04.12.2023 US 202363605646 P
28.03.2024 US 202463570955 P

(71) Applicant: Board of Trustees of Michigan State University
East Lansing, MI 48824 (US)

(72) Inventors:
  • AGUIRRE, Aitor
    Okemos, MI 48864 (US)
  • O'HERN, Colin, T.
    Lansing, MI 48910 (US)

(74) Representative: August Debouzy 
7, rue de Téhéran
75008 Paris
75008 Paris (FR)

   


(54) METHOD OF MAKING HUMAN HEART ORGANOIDS WITH INTEGRATED MACROPHAGES